Bulletproof your clinical laboratory with rugged and reliable LC-MS/MS instrumentation (Clinical diagnostic blog) by Pierre Negri | Jun 9, 2025 | Blogs, Clinical, Ion sourcesThe ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
Bulletproof your clinical laboratory with rugged and reliable LC-MS/MS instrumentation (Clinical research blog) by Pierre Negri | Jun 9, 2025 | Blogs, Clinical, Ion sourcesThe ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
Jon MacGregor by Jon MacGregor | Mar 7, 2024 | Ion sources, Other, Questions, ToxicologyI have a turbo v ion source that shows a glowing blue/purple light at the tip of the Heated Nebulizer corona discharge needle, even when it is not in use and turned out of ion path as it should be when using TIS probe. It only happens in negative mode. It is not arcing to the cutain plate, just a slight noticeable glow at the tip of the corona needle when observed through the front window. My FSE has rebuilt the HN probe and components and also installed a new TIS probe. Still glows when in negative mode. Note also having poor sensitivity in negative mode as well and jagged peak shapes during infusion. Any ideas? Are the symptoms related?
Source optimization by Trang Nguyen | Sep 11, 2023 | Ion sources, Optimizing Performance, QTRAP / Triple Quad, Questions, SCIEX OS softwareHello. I am setting up a new development method for analyzing toxic chemicals.
Overcoming N-nitrosamine analysis challenges with mass spectrometry and chromatography solutions by Kirsten Craven | Sep 6, 2023 | Blogs, Ion sources, Pharma, QTRAP / Triple QuadN-nitrosamine analysis has raised significant concerns in the pharmaceutical industry since 2018, when these potential carcinogens were found in several angiotensin II receptor blockers (sartans). Subsequent discoveries in ranitidine and some slow-release metformin medications prompted widespread product recalls. The industry has implemented stricter manufacturing requirements and intensified efforts to evaluate and control N-nitrosamine contamination. To meet stringent regulatory requirements, it is essential to develop effective chromatography and mass spectrometry (MS) methods for N-nitrosamine analysis. This blog addresses the challenges associated with detecting N-nitrosodimethylamine (NDMA) in metformin drug products.
General question on SCIEX 7500 by Dhayaalini Nadarajan | May 1, 2023 | Data acquisition, Ion sources, Questions, SCIEX OS software, TechnologyGood morning.
Easy switching of sources and LC flow regimes on the ZenoTOF 7600 system by Christie Hunter | May 9, 2022 | Data acquisition, Ion sources, Life Science Research, Proteomics, SCIEX information, ZenoTOF 7600 systemThis series of videos outlines how a user can easily switch sources and operate the system in different LC flow regimes.
Using Scheduled Ionization to reduce system ion load for proteomics data acquisition by Alexandra Antonoplis | Apr 29, 2022 | Data acquisition, Ion sources, Life Science Research, Proteomics, QTOF, QTRAP / Triple Quad, SCIEX information, SCIEX OS software, ZenoTOF 7600 systemWhen analyzing highly complex samples from biological matrices, there can be significant amounts of material that elute in the wash cycle of the LC run, depending on the up-front sample preparation used. The Scheduled Ionization mode, available in both SCIEX OS...
Adapting a SCIEX high flow source for microflow LC by Christie Hunter | Sep 20, 2021 | Data acquisition, Development, Ion sources, LC, Life Science Research, Metabolomics, Pharma, Proteomics, SCIEX informationTo set up a SCIEX high flow source for microflow LC (Turbo V ion source, DuoSpray source or IonDrive Turbo V ion source), first you must replace the wider bore electrodes with more narrow bore hybrid electrodes. Note with the OptiFlow Turbo V ion sources, there are...
Automatic calibration in minutes for microflow LC with the OptiFlow source on ZenoTOF 7600 system by Alexandra Antonoplis | Aug 7, 2021 | Bioanalysis/PK, Biopharma, Data acquisition, Ion sources, Life Science Research, Metabolomics, Pharma, Proteomics, SCIEX information, Technology, ZenoTOF 7600 systemThe OptiFlow ion source for the SCIEX ZenoTOF 7600 system is equipped with an ESI calibration probe for automatic calibration during microflow experiments (diagram below). The ESI probe is installed orthogonal to the microflow probe in the OptiFlow source and...